HPGDS inhibitor 1 ( H-PGDS Inhibitor I )

Catalog No. M10167 CAS No. 1033836-12-2

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Product Name

HPGDS inhibitor 1
Note

Research use only, not for human use.
Brief Description

A potent, selective, oral hematopoietic prostaglandin D synthase (HPGDS) inhibitor with enzyme IC50 of 0.6 nM.
Description

A potent, selective, oral hematopoietic prostaglandin D synthase (HPGDS) inhibitor with enzyme IC50 of 0.6 nM; does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5 LOX (IC50>10 uM); reduces the antigen-induced response in vivo.
Synonyms

H-PGDS Inhibitor I
Pathway

Immunology/Inflammation
Target

PGE synthase
Recptor

hPGDS
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1033836-12-2
Formula Weight

381.37
Molecular Formula

C19H19F4N3O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C1=CC=C(C2=CC=CC(F)=C2)N=C1)NC3CCN(CC(F)(F)F)CC3
Chemical Name

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-

1. Carron CP, et al. ACS Med Chem Lett. 2010 Feb 2;1(2):59-63.

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